| Autor: |
Wagenmann, M., Baroody, F. M., Jankowski, R., Nadal, J. C., Roecker-Cooper, M., Wood, C. C., Naclerio, R. M. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Allergy; Mar1994, Vol. 24 Issue 3, p288-290, 3p |
| Abstrakt: |
We performed a randomized, double-blind, placebo-controlled cross-over study with two different concentrations of ipratropium bromide (Atrovent®) nasal spray to evaluate its onset and duration of inhibition. Twenty-four subjects with perennial rhinitis participated in the trial. Fifteen minutes to 12 hours after administration of ipratropium bromide (42 or 168 μg/nostril) or placebo nasal spray, methacholine challenges were performed and nasal secretion weights measured. After placebo administration the effect of methacholine remained unchanged over the 12-h-period. Both the 42 and 168 μg/nostril doses significantly inhibited the nasal hypersecretions induced by methacholine challenge within 15 min of treatment (P<0 05). The 168 μg dose of ipratropium bromide continued to significantly reduce secretion weights through 6 hours, but the effectiveness of the 42 μg dose disappeared within 3 h. In addition to having a longer duration, the 168 μg/nostril dose produced approximately twice the inhibitory effect of the 42 μg dose. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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