| Abstrakt: |
There are many different nanomedicinal products for biomedical purposes such as metal nanoparticles. Silver nanoparticles are studied due to their catalytic, antibacterial properties and stability. It has also been reported that silver nanoparticles synthesized by green chemistry using plant sources that have antioxidant properties. Cotinus Coggygria, known as the smoke tree, has medically valuable antibacterial, antioxidant and wound healing compounds. Kappa-carrageenan (kappa-CRG) is a marine polysaccharide mostly used as food ingredient, but recently gained attention for biomedical purposes. Its gelling capacity, high viscosity, and biocompatibility, as well as its antioxidant, antiviral, antibacterial, etc. properties, make it a useful biopolymer for nanomedicine. In this study, silver nanoparticles and kappa-carrageenan coated silver nanoparticles were synthesized with the mixture obtained by adding varying amounts of kappa-carrageenan to Cotinus Coggygria extract. Silver nitrate was added to this mixture and allowed to react, then sonication was applied. After washing, a portion of samples were kept for 24 hours and DLS measurement performed. SEM, FTIR and antioxidant capacity analysis were also performed. DLS analysis revealed that coating with kappa-carrageenan reduced aggregation. FTIR analysis showed that the coating of silver nanoparticles was successful. Based on total reducing power analysis, the amount of inhibition of silver nanoparticles was 2-fold compared to ascorbic acid. In addition, although there was a slight decrease in the inhibition amount compared to silver nanoparticles with increased kappa-carrageenan coating, it still had almost twice the antioxidant capacity of ascorbic acid. According to the results, kappa-carrageenan coated silver nanoparticles have the potential to be used for biomedical purposes. [ABSTRACT FROM AUTHOR] |
