| Autor: |
Bouighi, S., Bendahmane, M., Beghdadli, B., Benalia, A., Djebbar, A. A., Tou, A. |
| Předmět: |
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| Zdroj: |
Journal of Experimental Research; Dec2022, Vol. 10 Issue 4, p221-229, 9p |
| Abstrakt: |
With more than 7000 chemical compounds, cigarette smoke; represents a major environmental risk to the health of the mother and her fetus. Nicotine is the main alkaloid of tobacco and is responsible for its addiction. The aim of our study is to assess the effects of nicotine on the uterus and the ovary of pregnant female rats. WISTAR rats with regular estrous cycle were divided into two equal groups; a control group and a group receiving 1mg/kg of nicotine daily from day 1 to day 19 of gestation. The rats were anaesthetized, their uteri and ovaries were removed, weighed and histologically examined. Serum estrogen and progesterone determinations were also performed. Our results showed that nicotine induced endometrial atrophy, follicular degeneration and a significant decrease in uterine weight and estrogen levels. Through these results, we suggest that gestational exposure of rats to nicotine affects steroidogenesis resulting in endometrial damage and follicular degeneration. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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