Preparation and Bioevaluation of Radioiodinated Omberacetam as a Radiotracer for Brain Imaging.

Autor:	Sanad, M. H., Marzook, F. A., Ibrahim, I. T., Abd-Elhalim, S. M., Farrag, N. S.
Předmět:	BRAIN imaging RADIOACTIVE tracers RADIOCHEMICAL purification OXIDIZING agents CHLORAMINE-T
Zdroj:	Radiochemistry; Feb2023, Vol. 65 Issue 1, p114-121, 8p
Abstrakt:	Radiosynthesis of a novel labeled brain tracer, [131I]iodoomberacetam, is described. The optimized oxidation conditions are as follows: substrate amount 100 µg, oxidizing agent (Chloramine-T) amount 100 µg, pH of reaction medium 5.0, reaction duration 30 min, and temperature 35–37°C. Under the optimum conditions, [131I]iodoomberacetam with the highest possible radiochemical purity (98%) was obtained. The brain uptake of [131I]iodoomberacetam was found to be as high as 9.66 ± 0.82% ID/g at 5 min post injection, according to a study of its biodistribution in mice. Thus, radioiodinated omberacetam shows promise as a novel radiopharmaceutical for brain imaging. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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