Cross-β helical filaments of Tau and TMEM106B in gray and white matter of multiple system tauopathy with presenile dementia.

Autor:	Hoq, Md. Rejaul, Bharath, Sakshibeedu R., Hallinan, Grace I., Fernandez, Anllely, Vago, Frank S., Ozcan, Kadir A., Li, Daoyi, Garringer, Holly J., Vidal, Ruben, Ghetti, Bernardino, Jiang, Wen
Předmět:	FRONTOTEMPORAL dementia WHITE matter (Nerve tissue) VOXEL-based morphometry TAU proteins FIBERS GRAY matter (Nerve tissue)
Zdroj:	Acta Neuropathologica; May2023, Vol. 145 Issue 5, p707-710, 4p
Abstrakt:	The gray matter contains nerve cell bodies, dendrites, axons, and synaptic terminals whereas the white matter contains axons as the only nerve cell component. Furthermore, additional studies of other neurodegenerative diseases are needed to establish whether amyloid filaments deriving from other proteins extracted from the gray and white matter would have identical folds like in MSTD. If future studies show that in genetically determined neurodegenerative diseases other amyloid proteins have identical filament cores in the gray and white matter, it might suggest that a common mechanism of misfolding takes place regardless of cell composition in different anatomical areas. [Extracted from the article]
Databáze:	Complementary Index
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