| Autor: |
Martín, María Plaza, Báez, Gemma Pastor, Cabello, Alfredo García, Stepanenko, Alexander, San Román Calvar, José Alberto, González, Aitor Uribarri |
| Předmět: |
|
| Zdroj: |
Perfusion; May2023, Vol. 38 Issue 4, p868-871, 4p |
| Abstrakt: |
Introduction: Propofol infusion syndrome (PRIS) is a rare entity that could lead to profound cardiogenic shock (CS). Mitochondrial toxicity and sympathetic blockade are the mechanisms leading to CS in PRIS. Case report: We present a 22-year-old woman who developed refractory CS due to PRIS after aortic valve replacement surgery secondary to Coxiella infective endocarditis. She was rescued with VA-ECMO (veno-arterial extracorporeal membrane oxygenation) and was discharged 2 months later with no cardiac dysfunction. Discussion: PRIS diagnosis is difficult even though propofol is frequently used in critical care units. Abrupt refractory CS in patients with recent use of high doses of propofol (> 4 mg/Kg/h) together with rhabdomyolysis should raise the suspicion. Diagnostic confirmation is based on muscle biopsy and fat enzyme analysis. Conclusion: Propofol withdrawal and support therapies—including VA-ECMO—are the treatment of choice in severe PRIS. VA-ECMO could increase survival as a bridge to recovery due to reversibility of PRIS. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
