| Autor: |
Skoglund, A.-C., Larsson, E.-L., Andersson, B. |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Immunology; Apr1983, Vol. 17 Issue 4, p355-363, 9p |
| Abstrakt: |
Murine splenic cells were separated on Ig -anti-Ig columns to yield cell populations depleted of IgM-FcR (Fc receptor)-expressing (TM-) and IgG-FcR-expressing (TG-) cells and also cells expressing neither of these two FcR (To). The proliferative response to the lectin concanavalin A (Con A) was shown to be present mainly in cell populations depleted of TM cells (T cells lacking IgM FcR.)-that is, TM- and To. The low Con A response in the other cell populations, namely TG- and TTOT was due to a selection against T-cell growth factor (TCGF> reactive cells, since TCGF production within these subsets was not impaired and the low proliferative response was not reconstituted by preformed TCGF. TG- cells were able to inhibit the Con-A-induced proliferation of To and TM- cells dose-dependently. These data strongly suggest the presence of a step-one regulatory, suppressive mechanism comprised within the TM population. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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