Crude dry extract from Colocasia esculenta in association with poly(vinyl alcohol) as biomaterial to prepare bioactive wound dressing.

Autor: de Prado, Elisabeth Maria López, de Paula, Geanne Aparecida, Dutra, Jessyca Aparecida Paes, Cipriano, Daniel Fernandes, Kitagawa, Rodrigo Rezende, Siman, Fabiana Dayse Magalhães, Meira, Eduardo Frizzera, de Freitas, Jair Carlos Checon, Severi, Juliana Aparecida, Carreira, Lílian Gasparelli, Oréfice, Rodrigo Lamberti, Villanova, Janaina Cecília Oliveira
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Zdroj: Polymer Bulletin; May2023, Vol. 80 Issue 5, p4783-4812, 30p
Abstrakt: Colocasia esculenta (taro) is traditionally reported to be rich in bioactive compounds with pharmacological properties, and it is a source of starch—a natural polymer with film-forming capacity. The present work aimed to use the crude dry extract from taro rhizome in high proportions to form polymeric films in association with PVA, for use as biomaterials to prepare wound dressing. The films prepared by solvent casting technique were analyzed to evaluate their physicochemical parameters, barrier, and mechanical properties, and in vitro biocompatibility, important attributes for the functionality and safety of films for wound dressing application. The starch contained in the taro extract showed good filmogenic properties after prior gelatinization in water and then blending with the PVA solution containing glycerol. Moreover, the films obtained were thin, smooth, transparent, shiny, and domain-free. SEM photomicrographs showed the existence of a continuous and homogeneous microstructure. Additionally, the blends were partially miscible and presented an altered crystalline structure. The thermal stability and mechanical resistance parameters were improved due to the presence of the taro extract. In addition, the parameters pertaining to the functionality of the films as wound dressings were improved, particularly in the films containing higher proportions of the extract, which is configured as an advantage, since the taro extract proved to be non-cytotoxic, biocompatible, with healing activity, and it comes from a renewable source. Crude extract from taro rhizome blended with PVA proved to be suitable for the intended purpose. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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