| Autor: |
Güney, Zeliha, Kurgan, Sivge, Önder, Canan, Mammadov, Cavid, Serdar, Muhittin A., Günhan, Meral |
| Předmět: |
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| Zdroj: |
Journal of Periodontal Research; Apr2023, Vol. 58 Issue 2, p256-261, 6p |
| Abstrakt: |
Objective: This study aimed to evaluate the level of ADMA (asymmetric dimethylarginine), SDMA (symmetric dimethylarginine), and IL-1β (Interleukin-1β) in gingival crevicular fluid (GCF) from periodontitis patients and control subjects. Background: ADMA and SDMA are potentially hazardous non-proteinogenic amino acids that limit nitric oxide (NO) synthesis and have many functions in various human disorders. ADMA causes a structural change in nitric oxide synthase, while SDMA blocks arginine cell uptake. Increased plasma ADMA has been widely recognized as a “trigger” initiating impaired NO bioavailability and vascular dysfunction, which ultimately leads to oxidative stress. Methods: Twenty-five patients with periodontitis (P) (Stage III, Grade C, n = 25) and 20 control (C) subjects were included in the study. The IL-1β level of GCF was measured by enzyme immunoassay (ELISA) and ADMA and SDMA by liquid chromatographymass spectrometry (LC–MS/MS). Results: Periodontitis patients had higher clinical parameters than controls (p< .001). Levels of IL-1β, ADMA and SDMA GCF were statistically significantly higher in group P than in group C (respectively; p = .003, p< .0001, p< .0001). There was no difference in the ADMA/SDMA ratio (p = .312) between the groups. There were significant positive correlations between clinical periodontal parameters and IL-1β, ADMA, and SDMA levels (p< .05). ADMA and SDMA levels were significantly correlated with IL-1β (p< .05).Conclusions: These findings suggest that ADMA and SDMA may be involved in the pathogenesis of the periodontal disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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