Effects of Methylprednisolone on the in Vitro Induction and Function of Suppressor Cells in Man.

Autor: Hirschberg, T., Randazzo, B., Hirschberg, H.
Předmět:
Zdroj: Scandinavian Journal of Immunology; Jul1980, Vol. 12 Issue 1, p33-39, 7p
Abstrakt: The effects of the steroid methylprednisolone on the induction of suppressor lymphocytes in human mixed lymphocyte cultures (MLC) have been examined, Concentrations of methylprednisolone (MP) sufficient lo inhibit both the cellular proliferation and the generation of cytotoxic lymphocytes in MLC appeared lo enhance the induction of suppressor cells in these cultures. Maximum enhancement of suppressor cell induction occurred at an MP concentration of approximately I μg/ml. Moreover, the presence of low concentrations of methylprednisolone. not sufficient to inhibit proliferation in MLC, significantly potentiated the inhibiting effect of suppressor cells on cellular proliferation. The inhibition observed by the combined effect of MP and suppressor cells was equivalent lo that seen using live times as many suppressor cells alone. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index