Patients with inflammatory myopathies overlapping with systemic sclerosis: A Brazilian-Japanese bicentric study.
| Autor: | Gonçalves Júnior, Jucier, Naoki Mugii, Pleiades Tiharu Inaoka, Miossi, Renata, Carlos De Souza, Fernando Henrique, Soares De Oliveira, João Calvino, Fujiko Someya, Yasuhito Hamaguchi, Takashi Matsushita, Degrava Sampaio-Barros, Percival, Shinjo, Samuel Katsuyuki |
|---|---|
| Předmět: |
RESEARCH
HEALTH facilities POLYMYOSITIS DERMATOMYOSITIS ULCERS IMMUNOGLOBULINS CROSS-sectional method ANTISYNTHETASE syndrome AGE distribution SYSTEMIC scleroderma RETROSPECTIVE studies DEGLUTITION disorders POPULATION geography ACQUISITION of data RISK assessment COMPARATIVE studies SEX distribution DESCRIPTIVE statistics MEDICAL records AGE factors in disease MYOSITIS SOCIODEMOGRAPHIC factors BLOOD testing LONGITUDINAL method DISEASE risk factors SYMPTOMS |
| Zdroj: | Archives of Rheumatology; Mar2023, Vol. 38 Issue 1, p138-147, 10p |
| Abstrakt: | Objectives: This study aims to describe and compare the demographic, clinical, and laboratory characteristics and follow-up of representative samples of patients with myopathies and systemic sclerosis overlap syndromes (Myo-SSc) from two tertiary centers. Patients and methods: This is a cross-sectional and retrospective study conducted between January 2000 and December 2020. Fourty-five patients were analyzed with Myo-SSc (6 males, 39 females; mean age: 50.2±15.4 years; range, 45 to 65 years) from two tertiary centers (n=30 from Brazil and n=15 from Japan). Results: The median follow-up was 98 (range, 37 to 168) months. Muscle impairment started simultaneously with the diagnosis of systemic sclerosis in 57.8% (26/45) of cases. Muscle involvement occurred before the onset of systemic sclerosis in 35.5% (16/45) of cases, and after in 6.7% (3/45). Polymyositis was observed in 55.6% (25/45) of cases, followed by dermatomyositis in 24.4% (11/45) and antisynthetase syndrome in 20.0% (9/45). Concerning systemic sclerosis, the diffuse and limited forms occurred in 64.4% (29/45) and 35.6% (16/45) of the cases, respectively. Comparing the subgroups, Myo or SSc onset was earlier in Brazilian patients, and they had a higher frequency of dysphagia (20/45, [66.7%]) and digital ulcers (27/45, [90%]), whereas Japanese patients had higher modified Rodnan skin scores (15 [9 to 23]) and prevalence of positive anti-centromere antibodies (4/15 [23.7%]). The current disease status and mortality were similar in both groups. Conclusion: In the present study, Myo-SSc affected middle-aged women, and its manifestation spectrum varied according to geographic distribution. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
| Externí odkaz: |
|