| Autor: |
Timi, Patience, Kellerhals, Sarah E, Joseph, Naima T, Dude, Carolynn M, Verkerke, Hans P, Irby, Les'Shon S, Smith, Alicia K, Stowell, Sean R, Jamieson, Denise J, Badell, Martina L |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; Apr2023, Vol. 227 Issue 7, p850-854, 5p |
| Abstrakt: |
Background We examined the relationship between placental histopathology and transplacental antibody transfer in pregnant patients after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods Differences in plasma concentrations of anti-receptor biding domain (RBD) immunoglobulin (Ig)G antibodies in maternal and cord blood were analyzed according to presence of placental injury. Results Median anti-RBD IgG concentrations in cord blood with placental injury (n = 7) did not differ significantly from those without injury (n = 16) (median 2.7 [interquartile range {IQR}, 1.8–3.6] vs 2.7 [IQR, 2.4–2.9], P = 0.59). However, they were associated with lower transfer ratios (median 0.77 [IQR, 0.61–0.97] vs 0.97 [IQR, 0.80–1.01], P = 0.05). Conclusions SARS-CoV-2 placental injury may mediate reduced maternal-fetal antibody transfer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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