| Autor: |
Feucht, H. E., Felber, E., Gokel, M. J., Hillebrand, G., Natterman, U., Brockmeyer, C., Held, E., RiethmÜller, G., Land, W., Albert, E. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Dec1991, Vol. 86 Issue 3, p464-470, 7p |
| Abstrakt: |
Complement activation in 73 renal transplant biopsies was investigated by indirect immunoperoxidase staining using MoAbs reactive with complement-split products. Intense deposition of complement fragments C4d and C3d in peritubular capillaries, indicating activation of the classical pathway, could be detected in the majority of transplanted kidneys with cell-mediated rejections. Abundant deposition of complement-split products was observed in 22 early biopsies from patients with high 'immunological risk' (i.e. previous, rejected transplants and/or circulating antibodies against HLA-antigens), Despite negative results in the crossmatch before transplantation and paucity of immunoglobulins in transplant biopsies, antibodies directed against endothelial cell antigens should be considered as a possible cause of classical complement activation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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