Melanoma Clinical Decision Support System: An Artificial Intelligence-Based Tool to Diagnose and Predict Disease Outcome in Early-Stage Melanoma Patients.

Autor: Diaz-Ramón, Jose Luis, Gardeazabal, Jesus, Izu, Rosa Maria, Garrote, Estibaliz, Rasero, Javier, Apraiz, Aintzane, Penas, Cristina, Seijo, Sandra, Lopez-Saratxaga, Cristina, De la Peña, Pedro Maria, Sanchez-Diaz, Ana, Cancho-Galan, Goikoane, Velasco, Veronica, Sevilla, Arrate, Fernandez, David, Cuenca, Iciar, Cortes, Jesus María, Alonso, Santos, Asumendi, Aintzane, Boyano, María Dolores
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Zdroj: Cancers; Apr2023, Vol. 15 Issue 7, p2174, 16p
Abstrakt: Simple Summary: Early diagnosis and accurate prognosis is essential to personalize treatment and improve the survival of melanoma patients. We report here a new tool that can improve the early diagnosis of melanoma through the use of epiluminescence dermatoscopy and deep learning image analysis. By employing artificial intelligence algorithms to analyze simple serological and histopathological biomarkers, the risk of metastasis and the disease-free interval of melanoma patients can be accurately predicted. This low-cost Melanoma Clinical Decision Support System represents an effective tool to help clinicians manage melanoma patients. This study set out to assess the performance of an artificial intelligence (AI) algorithm based on clinical data and dermatoscopic imaging for the early diagnosis of melanoma, and its capacity to define the metastatic progression of melanoma through serological and histopathological biomarkers, enabling dermatologists to make more informed decisions about patient management. Integrated analysis of demographic data, images of the skin lesions, and serum and histopathological markers were analyzed in a group of 196 patients with melanoma. The interleukins (ILs) IL-4, IL-6, IL-10, and IL-17A as well as IFNγ (interferon), GM-CSF (granulocyte and macrophage colony-stimulating factor), TGFβ (transforming growth factor), and the protein DCD (dermcidin) were quantified in the serum of melanoma patients at the time of diagnosis, and the expression of the RKIP, PIRIN, BCL2, BCL3, MITF, and ANXA5 proteins was detected by immunohistochemistry (IHC) in melanoma biopsies. An AI algorithm was used to improve the early diagnosis of melanoma and to predict the risk of metastasis and of disease-free survival. Two models were obtained to predict metastasis (including "all patients" or only patients "at early stages of melanoma"), and a series of attributes were seen to predict the progression of metastasis: Breslow thickness, infiltrating BCL-2 expressing lymphocytes, and IL-4 and IL-6 serum levels. Importantly, a decrease in serum GM-CSF seems to be a marker of poor prognosis in patients with early-stage melanomas. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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