Long noncoding RNA SNHG7‐miRNA‐mRNA axes crosstalk with oncogenic signaling pathways in human cancers.

Autor:	Malakoti, Faezeh, Alemi, Forough, Yeganeh, Shirin Jafari, Hosseini, Foroogh, Shabestani, Nazila, Samemaleki, Sahar, Maleki, Masomeh, Daneshvar, Sarvin Fathi, Montazer, Majid, Yousefi, Bahman
Předmět:	LINCRNA CELLULAR signal transduction NON-coding RNA CARCINOGENESIS CANCER invasiveness MICRORNA
Zdroj:	Chemical Biology & Drug Design; May2023, Vol. 101 Issue 5, p1151-1161, 11p
Abstrakt:	LncRNAs and miRNAs are the two most important non‐coding RNAs, which have been identified to be associated with cancer progression or prevention. The dysregulation of lncRNAs conducts tumorigenesis and metastasis in different ways. One of the mechanisms is that lncRNAs interact with miRNAs to regulate distinct cellular and genomic processes and cancer progression. LncRNA SNHG7 as an oncogene sponges miRNAs and develops lncRNA‐miRNA‐mRNA axes, leading to the regulation of several signaling pathways such as Wnt/β‐Catenin, PI3K/AKT/mTOR, SIRT1, and Snail‐EMT. Therefore, in this article, after a brief overview of lncRNA SNHG7‐miRNA‐mRNA axes' contribution to cancer development, we will discuss the role of lncRNA SNHG7 in the genes expression and signaling pathways related to cancers development via acting as a ceRNA. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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