| Abstrakt: |
Mitochondria as dynamic organelles go through coordinated processes, including fusion and apoptosis. This study was designed to assess the effects of L-carnitine supplement and high-intensity training on the mitochondria fusion and apoptosis in liver tissue. Thirty-two Wistar rats were assigned into four groups, and eight rats were entered into each group, including the untreated control group (CTL), L-Carnitine group (LCAR; 200 mg/kg/day, i.p), High-intensity interval training group (HIIT), HIIT+L-Carnitine group (LCAR-HIIT; received 200 mg/kg/day L-Carnitine and performed HIIT). Real-Time PCR was used to quantify the expression of liver genes. LCAR-HIIT significantly decreased Parkin (p<0.0001), MFN-1 (p=0.014), Caspase-3 (p=0.039), Bax (p<0.0001) expression in the liver compared with the CTL. However, HIIT with LCAR significantly increased the expression of Bcl-2 compared with the CTL (p=0.049), while LCAR significantly reduced Bax expression compared to the CTL (p=0.006). LCAR-HIIT induced positive physiological changes in the liver through negative regulation of Bax and caspase-3. In addition, LCAR-HIIT may provide a new approach for ameliorating mitochondria fusion in the liver tissue. [ABSTRACT FROM AUTHOR] |
