| Autor: |
SAXENA, Rishika, SINGH, Om Prakash, YOGI, Veenita, YADAV, Suresh, PATHAK, Pushpraj Kumar, GHORI, Hameed Uzzafar, TIWARI, Vivek, CHOUDHARY, Megha, SAXENA, Sachet |
| Předmět: |
|
| Zdroj: |
Turkish Journal of Oncology / Türk Onkoloji Dergisi; 2023, Vol. 38 Issue 1, p36-44, 9p |
| Abstrakt: |
OBJECTIVE In this study, we analyzed dose to organ at risk in the left breast cancer patients, in terms of dose volume histogram (DVH), with the quantitative analysis of normal tissue effects in the clinic dose constraints and calculate potential toxicity in terms of normal tissue complication probability (NTCP). METHODS This study included 60 post-operated left breast cancer patients who received chest wall/breast irradiation by three-dimensional conformal radiotherapy (RT). The patients had received a total dose of 40Gy in 15 fractions to whole breast/chest wall (two fields) and dose to supraclavicular fossa (three fields). We compared the DVH for heart, lung, and spinal cord in both fields. RESULTS Mean dose for lung was 17.49Gy and for heart 12.31Gy, and spinal cord maximum dose was 0.78Gy. The average lung NTCP for RP was 3.11%. The risk of RP was significantly greater in three-field radiation as compared to two field for lung (p<0.05). We observed the statistically significant correlation of MHD and NTCP (p<0.00001 and p=0.000402). The correlation of central lung distance (CLD) was observed to be significant with three fields, that is, as the CLD increased risk of organ damage to lungs increased (p=0.00022). The correlation of CLD and MHD with DVH was observed to be statistically significant (p<0.001). CONCLUSION This study results are useful to reanalyze the previous 2D-based clinical reports about breast RT complications as a view point of the NTCP. Further studies are needed for the actual clinical data of complications with this DVH analysis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
