Sodium hypophosphite mediated reductive amination of carbonyl compounds with N,N-dialkylformamides.

Autor: Fatkulin, Artemy R., Korochantsev, Vasily, Afanasyev, Oleg I., Podyacheva, Evgeniya, Chusova, Olga, Muratov, Dmitry V., Godovikova, Maria I., Semenov, Sergei, Chusov, Denis
Předmět:
Zdroj: New Journal of Chemistry; 4/14/2023, Vol. 47 Issue 14, p6532-6535, 4p
Abstrakt: Herein we report a transition-metal- and acid-free protocol for the reductive amination of carbonyl compounds with DMF using a substoichiometric amount of NaH2PO2·H2O. A set of various N,N-dimethylamines were obtained in moderate to excellent yields without chromatographic purification. The general trends and limitations of the method with different formamides as sources of dialkyl-fragments were explored. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index