| Autor: |
Akamatsu, Hayato, Nakagawa, Hiroo, Matsumaru, Ichiro, Hashizume, Junya, Harasawa, Hitomi, Kodama, Yukinobu, Miura, Takashi, Ohyama, Kaname |
| Předmět: |
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| Zdroj: |
Journal of Pharmaceutical Health Care & Sciences; 4/1/2023, Vol. 9 Issue 1, p1-4, 4p |
| Abstrakt: |
Background: Fluconazole (FLCZ) inhibits cytochrome P450 (CYP) 2C9, 2C19, and 3A4 and has a drug-drug interaction that potentiates the effects of warfarin and prolong the prothrombin time-international normalized ratio (PT-INR). Although a drug-drug interaction have been reported between FLCZ and warfarin, the effects of the timing of their administration on this interaction have not yet been investigated. Case presentation: A female patient in her 30s with Marfan syndrome had undergone the Bentall procedure with a mechanical valve and total arch replacement for acute aortic dissection Stanford A type and rupture of the ascending aorta. Warfarin was administered to prevent thromboembolism. She was hospitalized 1 year ago for graft infection caused by Candida albicans, and treatment with FLCZ was initiated. She received FLCZ 200 mg once a day in the morning and warfarin 1.75 mg once a day in the evening, and the PT-INR remained stable at approximately 2.0 and within the therapeutic range. However, 42 days after changing the timing of administration of warfarin from evening to morning, the PT-INR was prolonged by approximately 3-fold to 6.25. The PT-INR then decreased to the previous level by changing the timing of administration of warfarin from morning to evening. Conclusions: The timing of administration of FLCZ and warfarin may affect the magnitude of drug-drug interaction. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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