DNA labelling in live cells via visible light-induced [2+2] photocycloaddition.

Autor: Michenfelder, Rita T., Delafresnaye, Laura, Truong, Vinh X., Barner-Kowollik, Christopher, Wagenknecht, Hans-Achim
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Zdroj: Chemical Communications; 4/7/2023, Vol. 59 Issue 27, p4012-4015, 4p
Abstrakt: We introduce a visible light-driven (λmax = 451 nm) photo-chemical strategy for labelling of DNA in living HeLa cells via the [2+2] cycloaddition of a styrylquinoxaline moiety, which we incorporate into both the DNA and the fluorescent label. Our methodology offers advanced opportunities for the mild remote labelling of DNA in water while avoiding UV light activation. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index