Vasa, a regulator of localized mRNA translation on the spindle.

Autor:	Sundaram Buitrago, Paola Alejandra, Rao, Kavya, Yajima, Mamiko
Předmět:	MESSENGER RNA SEA urchins CELLULAR control mechanisms EMBRYOLOGY RNA metabolism CANCER cells DNA helicases
Zdroj:	BioEssays; Apr2023, Vol. 45 Issue 4, p1-11, 11p
Abstrakt:	Localized mRNA translation is a biological process that allows mRNA to be translated on‐site, which is proposed to provide fine control in protein regulation, both spatially and temporally within a cell. We recently reported that Vasa, an RNA‐helicase, is a promising factor that appears to regulate this process on the spindle during the embryonic development of the sea urchin, yet the detailed roles and functional mechanisms of Vasa in this process are still largely unknown. In this review article, to elucidate these remaining questions, we first summarize the prior knowledge and our recent findings in the area of Vasa research and further discuss how Vasa may function in localized mRNA translation, contributing to efficient protein regulation during rapid embryogenesis and cancer cell regulation. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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