| Abstrakt: |
Background: - Even though hormone replacement therapy with thyroxine has been proven effective in its management, but owing to adverse effects like angina, myocardial infarction, arrhythmias, anxiety, insomnia, immunoallergic hepatitis, decreased bone mineral density. Commiphora mukul (Muqil) activates the production of thyroid hormones Thyroxine (T4), Triiodothyronine (T3), and improves hypothyroidism. Its lipid lowering effect is also related to its thyroid activity.2-Guggulestrone-a ketosteroid counteracts the thyroid suppressant activity of carbimazole. Its thermogenic effect helps in cold intolerance of hypothyroid patients. Material and methods: The study was carried out at Regional Research Institute of Unani Medicine (RRIUM) Srinagar Jammu & Kashmir after approval by Institutional Ethical Committee. Hypothyroid patients fulfilling the inclusion and exclusion criteria were given Commiphora mukul 1 gm twice daily in the morning after breakfast and another dose in the evening to each patient with luke warm water. On enrolling and every follow up, patients were assessed for their symptoms and sampled for TSH, T3, T4, and adverse drug reactions. Conclusion:The drug causes subjective improvement on cold intolerance as well as objective improvement in TSH levels, indicating a thyroxine like effect rather than causing increase in T3 and T4, but it needs to be deciphered further. [ABSTRACT FROM AUTHOR] |
