| Abstrakt: |
"Sofpironium bromide is a quaternary ammonium salt compound represented by the following formula (I) (BBI-4000, (2R,3'R)-3'-(2-cyclopentyl-2-hydroxy-2-phenylacetyl)-1'-(ethoxycarbonylmethyl)-1'-methylpyrrolidinium bromide). "Another object to be achieved by the present invention is to provide highly purified sofpironium bromide, in particular, a physicochemically stable crystalline form of high-purity sofpironium bromide." "More specifically, sofpironium bromide is a mixture of (2R,3'R,1'R)-3'-(2-cyclopentyl-2-hydroxy-2-phenylacetyl)-1'-(ethoxycarbonylmethyl)-1'-methylpyrrolidinium bromide represented by the following formula (I-a): "(in the specification, the aforementioned 1'R-diastereomer is henceforth also referred to as compound (I-a) ) and (2R,3'R,1'S)-3'-(2-cyclopentyl-2-hydroxy-2-phenylacetyl)-1'-(ethoxycarbonylmethyl)-1'-methylpyrrolidinium bromide represented by the following formula (I-b): "(in the specification, the aforementioned 1'S-diastereomer is henceforth also referred to as compound (I-b) ). [Extracted from the article] |
