| Autor: |
Nguyen, Thi-Quynh-Trang, Pham, Nguyen-Kim-Tuyen, Trung, Nguyen Tien, An, Nguyen Truong, Mai, Dinh-Tri, Sichaem, Jirapast, Huynh, Bui-Linh-Chi, Anh, Nguyen Thi Hong, Nguyen, Ngoc-Hong, Duong, Thuc-Huy |
| Předmět: |
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| Zdroj: |
Natural Product Research; Apr2023, Vol. 37 Issue 8, p1284-1291, 8p |
| Abstrakt: |
One new hopane-type triterpene, indicuen (1), along with eight known compounds (2–9) were isolated from the n-hexane extract of the lichen Parmotrema indicum Hale. The chemical structures of isolated compounds were identified by interpretation of their spectroscopic data (1D, 2D NMR and HRESIMS) combined with DFT-NMR chemical shift calculations and subsequent assignment of DP4+ probabilities and by comparison with the literature. Indicuen represents for a rare hopane bearing a 1-carboxyethyl substituent at C-21 in lichens. Compounds 1–3 and 5–8 were evaluated for α-glucosidase inhibition and cytotoxicity against K562 and HepG2 cancer cell lines. Compounds 1, 5 and 7 exhibited moderate α-glucosidase inhibition with IC50 values of 201.1, 156.3 and 187.4 µM, respectively. Compound 1 also showed weak cytotoxicity toward K562 cell line while others showed no activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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