| Autor: |
Chen, Chih-Hsin, Cretekos, Chris J., Rasweiler IV, John J., Behringer, Richard R. |
| Předmět: |
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| Zdroj: |
Evolution & Development; Mar/Apr2005, Vol. 7 Issue 2, p130-141, 12p |
| Abstrakt: |
Bat forelimbs are highly specialized for sustained flight, providing a unique model to explore the genetic programs that regulate vertebrate limb diversity.Hoxd9–13genes are important regulators of stylopodium, zeugopodium, and autopodium development and thus evolutionary changes in their expression profiles and biochemical activities may contribute to divergent limb morphologies in vertebrates. We have isolated the genomic region that includesHoxd12andHoxd13fromCarollia perspicillata, the short-tailed fruit bat. The batHoxd13gene encodes a protein that shares 95% identity with human and mouse HOXD13. The expression pattern of batHoxd13mRNA during limb development was compared with that of mouse. In bat and mouse hindlimbs, the expression patterns ofHoxd13are relatively similar. However, although the forelimbHoxd13expression patterns in both organisms during early limb bud stages are similar, at later stages they diverge; the anterior expression boundary of batHoxd13is posterior-shifted relative to the mouse. These findings, compared with theHoxd13expression profiles of other vertebrates, suggest that divergentHoxd13expression patterns may contribute to limb morphological variation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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