| Abstrakt: |
"According to various embodiments of the disclosure, the topical Fenoldopam compositions can be an anhydrous composition or a water-containing composition. Unexpectedly, Applicants of the present disclosure were able to overcome the solubility and stability challenges of Fenoldopam as the active ingredient and to develop topical compositions comprising a therapeutically effective amount of Fenoldopam with at least 0.1% by weight of Fenoldopam. The topical composition according to claim 1, wherein the amount of the at least one polyacrylamide-type gelling agent in the composition is about 1% to about 5% by weight of the composition. The topical composition according to claim 1, wherein the weight percentage of Fenoldopam in the composition is between 90%-110% of the label claim of Fenoldopam for at least one month. [Extracted from the article] |
