Goal-directed perfusion for reducing acute kidney injury in cardiac surgery: A systematic review and meta-analysis.
| Autor: | Gao, Peng, Liu, Jinping, Zhang, Peiyao, Bai, Liting, Jin, Yu, Li, Yixuan |
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| Předmět: |
PREVENTION of surgical complications
ACUTE kidney failure prevention MORTALITY prevention CARDIAC surgery MEDICAL databases META-analysis MEDICAL information storage & retrieval systems CONFIDENCE intervals SYSTEMATIC reviews DESCRIPTIVE statistics RESEARCH funding MEDLINE CARDIOPULMONARY bypass ODDS ratio PERFUSION ACUTE kidney failure |
| Zdroj: | Perfusion; Apr2023, Vol. 38 Issue 3, p591-599, 9p |
| Abstrakt: | Background: Acute kidney injury (AKI) is a common complication following cardiopulmonary bypass (CPB) which can affect morbidity and mortality. Goal-directed perfusion (GDP) intended to avoid the nadir oxygen delivery index below the critical value is associated with reduced postoperative AKI. However, current studies suggested that GDP can only decrease the incidence of AKI stage 1 but showed no effects on AKI stages 2–3 and mortality. The objective of the present meta-analysis is to deter the effects of GDP on postoperative AKI in any stage and mortality following cardiac surgery. Methods: MEDLINE, Embase, and the Cochrane Library were searched to identify all clinical trials comparing GDP with control (standard care) during cardiopulmonary bypass conducting in adults undergoing cardiac surgery. The primary outcome was postoperative acute kidney injury. Secondary outcomes included postoperative mortality and length of ICU stay. Data synthesis was obtained by using risk ratio with 95% confidence interval by a random-effects model. Result: From 1094 potential studies, 3 trials enrolling 777 patients were included. Meta-analysis suggested the GDP strategy based on DO |
| Databáze: | Complementary Index |
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