| Autor: |
Kahn, Ryan Matthew, Ahsan, Muhammad Danyal, Chapman-Davis, Eloise, Holcomb, Kevin, Nitecki, Roni, Rauh-Hain, Jose Alejandro, Fowlkes, Rana Khan, Tubito, Francesca, Pires, Maira, Christos, Paul J, Tkachuk, Kaitlyn, Krinsky, Hannah, Sharaf, Ravi N., Offit, Kenneth, Lipkin, Steven, Frey, Melissa K. |
| Předmět: |
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| Zdroj: |
Familial Cancer; Apr2023, Vol. 22 Issue 2, p127-133, 7p |
| Abstrakt: |
Cascade testing for familial cancer syndromes has historically been difficult to execute. As part of a facilitated cascade testing pathway, we evaluated barriers to completion of cascade testing. Our previously published study evaluated a facilitated cascade testing pathway whereby a genetics team facilitated at-risk relative (ARR) cascade testing through telephone genetic counseling and mailed saliva kit testing. This follow-up study evaluated barriers to completion of cascade genetic testing through six-month follow-up telephone interviews. Probands identified 114 ARRs, of whom 97 were successfully contacted by telephone. Among those contacted, 83 (86%) reported interest in genetic testing and 14 (14%) declined. Among those reporting interest in testing, 71% (69/83) completed testing. Follow-up telephone interviews revealed that 14 ARRs did not complete testing despite reporting interest for the following reasons: concern about genetic discrimination, fear of a positive result and belief that the pathogenic variant was not relevant to his/her health. Five ARRs reported that they remained interested in testing and the telephone call prompted completion of testing. Even when facilitated by a medical team with prioritization of relative convenience, significant barriers to cascade testing ARRs for hereditary breast and ovarian cancer syndrome persist due to concern about genetic discrimination, cost, and fear of positive test results. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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Full text from SpringerLink