| Autor: |
Medeiros, Roseane P., Terrault, Norah A., Mazo, Daniel F., Oliveira, Claudia P., Dodge, Jennifer, Zitelli, Patricia M., Lopes, Marta H., Carrilho, Flair J., Pesso, Mário G. |
| Předmět: |
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| Zdroj: |
Annals of Hepatology: Official Journal of the Mexican Association of Hepatology; Mar/Apr2023, Vol. 28 Issue 2, p1-6, 6p |
| Abstrakt: |
Introduction and Objectives: Some studies suggest chronic HCV infection diminishes responses to the anti- HBV vaccine. We evaluated the efficacy of double versus standard dose HBV vaccination among HCV patients without cirrhosis. Patients and Methods: 141 adults with untreated chronic HCV were randomized to HBV vaccination with double dose (40mg) or standard dose (20mg) at 0, 1 and 6 months; 70 healthy HCV-negative patients given standard dose served as controls. Vaccine response was defined by anti-HBs ≥10 mIU/mL. Results: 128 patients (60 double, 68 standard doses) completed the study. Patients were of median age 52 years, 61% female, 60% fibrosis <2 of 4, and 76% genotype 1 with median 6-log 10 IU/mL HCV RNA. Overall seroprotection rate was 76.7% (95% CI: 65-87) in the 40mg versus 73.5% (95% CI: 63-84) in the 20mg dose HCV-positive groups (p =0.68) and 91.2% (95%CI:84-99) in HCV-negative controls (p =0.011 and 0.003, respectively). In multivariate logistic regression, vaccine dose (double vs. standard dose) was not associated with vaccine response (OR=0.63, p =0.33). Of 32 HCV-infected patients who were non-responders to 3- doses, 25 received the fourth dose of vaccine. The fourth dose seroconversion rate for the 40mg and 20mg groups were 45.5% and 21.4%, respectively. Conclusions: In HCV-infected patients without cirrhosis, impaired responses to HBV vaccination cannot be overcome by the use of double dose HBV vaccination, but adding a fourth dose of vaccine for non-responders may be an effective strategy. Other adjuvant measures are needed to enhance seroconversion rates in these patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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