| Autor: |
Lucio-Martínez, Fátima, Esteban-Gómez, David, Valencia, Laura, Horváth, Dávid, Szücs, Dániel, Fekete, Anikó, Szikra, Dezső, Tircsó, Gyula, Platas-Iglesias, Carlos |
| Předmět: |
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| Zdroj: |
Chemical Communications; 3/21/2023, Vol. 59 Issue 23, p3443-3446, 4p |
| Abstrakt: |
Octadentate ligands containing ethyl (H4OCTAPA), cyclohexyl (H4CHXOCTAPA) or cyclopentyl (H4CpOCTAPA) spacers were assessed as chelators for Bi(III)-based radiopharmaceuticals. The H4CHXOCTAPA chelator displays excellent properties, including 205/206Bi-nuclide radiolabelling under mild conditions, excellent stability in serum and in the presence of competing cations or H5DTPA. The poor performance of H4CpOCTAPA appears to be related to the stereochemical activity of the Bi(III) lone pair. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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