| Autor: |
Zhou, Hai-Feng, Wang, Jia-Lei, Yang, Wei, Zhou, Chun, Shen, Yan, Wu, Ling-Ling, Pei, Zhong-Ling, Zhou, Wei-Zhong, Liu, Sheng, Shi, Hai-Bin |
| Předmět: |
|
| Zdroj: |
Surgical Endoscopy & Other Interventional Techniques; Mar2023, Vol. 37 Issue 3, p1943-1955, 13p |
| Abstrakt: |
Background: Patients with pancreatic cancer-caused biliary obstruction (PC-BO) have poor prognosis, but we lack of tools to predict survival for clinical decision-making. This study aims to establish a model for survival prediction among patients with PC-BO. Methods: A total of 172 patients with PC-BO treated with percutaneous biliary drainage were randomly divided into a training group (n = 120) and a validation group (n = 52). The independent risk factors for overall survival were selected to develop a Cox model. The predictive performance of M stage, hepatic metastases, cancer antigen 199, and the Cox model was determined. Naples prognostic score (NPS), the prognostic nutritional index (PNI), and the controlling nutritional status (CONUT) for 1-month mortality risk were compared with the Cox model. Results: The Cox model was developed based on total cholesterol, direct bilirubin, hepatic metastases, cancer antigen 199, stenosis type, and preprocedural infection (all P < 0.05), which named "COMBO-PaS." The COMBO-PaS model had the highest area under the curves (AUC) (0.801–0.933) comparing with other predictors (0.506–0.740) for 1-, 3-, and 6-month survival prediction. For 1-month mortality risk prediction, the COMBO-PaS model had the highest AUC of 0.829 comparing with NPS, PNI, and CONUT. Conclusion: The COMBO-PaS model was useful for survival prediction among patients with PC-BO. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
