| Autor: |
Wang, Ke, Jalil, Abduladheem Turki, Saleh, Marwan Mahmood, Talaei, Sona, Wang, Linlin |
| Zdroj: |
Chemical Papers; Apr2023, Vol. 77 Issue 4, p1921-1928, 8p |
| Abstrakt: |
Glioblastoma is one of the serious cancer in the world that treatment methods of this tumor through conventional methods such as surgery and chemotherapeutics are challenging due to difficult accessibility and blood–brain barrier (BBB). Here, in order to have appropriate efficacy of glioblastoma treatment with radiotherapy we developed targeted nanoradiosensitizer, which can be a promising procedure in favor of decreasing dosage of radiation. In this study, bismuth sulfide (Bi2S3) as a radiosensitizer agent with high atomic number coated with bovine serum albumin, which introduced high chemical stability, nontoxicity, and biodegradability to synthesized nanoparticles. Glutathione is also employed in this designing as the BBB shuttle peptide. After characterization of this designing through the FeSEM, DLS, FTIR and XRD, whose efficacy of treatment on cancer cell line (U87) is accomplished through the MTT, apoptosis, ROS and calcein AM/PI in presence and absence of X-ray. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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