An increased disulfide/native thiol ratio and oxidative stress index in metabolic syndrome patients with postprandial lipemia.

Autor: Ozer Yaman, Serap, Balaban Yucesan, Fulya, Orem, Asım, Orem, Cihan, Vanizor Kural, Birgul, Yaman, Huseyin
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Zdroj: International Journal of Diabetes in Developing Countries; Feb2023, Vol. 43 Issue 1, p125-133, 9p
Abstrakt: Background: Metabolic syndrome (MetS) is closely related to lipid disorders and increased oxidant stress, and is associated with cardiovascular diseases. Objective: The purpose of this research was to examine thiol/disulfide homeostasis and oxidative stress in MetS patients with postprandial lipemia (PPL) during fasting by considering time-dependent changes in the postprandial period. Methods: Twenty-five patients with MetS and 25 healthy controls underwent a 6-h oral fat tolerance test. Dynamic thiol/disulfide homeostasis (native thiol, disulfide, and total thiol) values and total oxidant status (TOS), total antioxidant status (TAS), and Oxidative Stress Index (OSI): (TOS/TAS) were evaluated. Results: Increased levels of disulfide, and higher disulfide/native thiol ratio, TOS, and OSI values were observed at fasting and in the postprandial period in MetS compared to the control group, peaking at the 4th hour in both groups (p < 0.05). ROC analysis showed that both fasting and 4th hour disulfide/native thiol ratios exhibited the highest values. Higher disulfide/native thiol ratio values were observed at the 4th hour and higher OSI in the 2nd hour in the upper tertiles for MetS (p < 0.05). Conclusions: An increased disulfide/native thiol ratio and OSI level elevation in MetS may be closely associated with PPL. The disulfide/native thiol ratio in MetS subjects with PPL may play a role for evaluating oxidative stress, especially in postprandial 4th hour. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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