Major Adverse Cardiovascular Events in Patients Starting Peritoneal Dialysis Based on the CKD-EPI Versus Thai eGFR Equation: A Retrospective Cohort Study.

Autor: Chaichaya, Nathaphop, Thinkhamrop, Bandit, Tatiyanupanwong, Sajja, Morley, Katharine, Morley, Michael, Thinkhamrop, Wilaiphorn, Laohasiriwong, Wongsa
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Zdroj: Medico-Legal Update; Oct-Dec2020, Vol. 20 Issue 4, p1763-1770, 8p
Abstrakt: Background: Major adverse cardiovascular events (MACE) are the leading cause of deathin chronic kidney disease (CKD) patients. The relationship between the initiation of peritoneal dialysis (PD) and MACE is unclear. Objective: This study compared the incidence of MACE in PD patients when the estimated- glomerular filtration rate (eGFR) is calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD- EPI) equation with the Thai eGFR equation. Method: The study was conducted among 684 end-stage CKD patients in a referral hospital in Thailand between 2011-2018. The first occurrence of cardiovascular events related MACE was defined as dependent variable. Logistic regression was used to identify the relationship. Results: The incidence of MACE was different between CKD-EPI group (10.9%) and Thai eGFR group (12.4%). After adjusting for other factors, the PD initiation using eGFR calculated by CKD-EPI equation did not affect the incidence of MACE when compared to those from Thai eGFR equation (Ajd.OR: 1.11; 95%CI: 0.68-1.82, P-value = 0.685). Conclusion: There was no effect on incidence of MACE when PD was initiated based on eGFR calculated using the CKD-EPI equation compared with the Thai eGFR equation. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index