| Autor: |
Hassan, Ali Faris, Abbas, Ruaa Fadhil, Al-Shawi, Nada Naji, Numan, Intesar Tarik |
| Předmět: |
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| Zdroj: |
Medico-Legal Update; Oct-Dec2020, Vol. 20 Issue 4, p963-968, 6p |
| Abstrakt: |
Doxorubicinisa chemotherapeutic drug that showed a great treatment potential, unfortunately, itis not-selective to cancer cells and affects many other cells. Vitamin K-7 is available from nutritional sources and dietary supplements,it has been reported that it had many beneficial effects. Objective: Evaluate the protective effect of vitamin K-7 against cytotoxicity and genotoxicity induced by doxorubicin. Method: Seventy-two rats divided equally into two groups, each group divided into 6 subgroups as following Group I: received distilled water. Group II: receiveda single dose of Doxorubicin (15mg/kg). Group III: received Vitamin K-7(16μg/kg) for 11 successive days. Group IV: received Vitamin K-7 (48μg/kg) for 11 successive days.Group V: received Vitamin K-7(16μg/kg) for 11 consecutive days before a single dose of Doxorubicin 15mg/kg on day11. Group VI: received Vitamin K-7 at a dose of 48 μg/kg for 11 consecutive days before a single dose of Doxorubicin 15 mg/kgat day 11. Results: Group II caused significant reduction (P<0.05) in mitotic index associated with an elevation in the micronucleus appearance and the total chromosomal aberrations compared to those of control Group I rats; meanwhile, Groups IV and V decreased chromosomal aberration, micronucleus appearance and increase mitotic index compared to Group II rats treated with doxorubicin. Conclusion: Vitamin K-7 has protective effects against genotoxicity and cytotoxicity induced by doxorubicin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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