Testosterone and Progesterone Levels, Gene Expression of Androgen and Progesterone Receptors in Albino Male Rats Treated with Phenolic Flower Extract of Hibiscus Rosa - Sinensis L.
| Autor: | AL-Azawi, Rawaa S. A., Al-hady, Faris N. A. |
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| Předmět: |
PHYTOTHERAPY
THERAPEUTIC use of flowers DRUG efficacy BIOLOGICAL models WOUND healing ANTIPARASITIC agents BIOMARKERS HIBISCUS PROGESTERONE BODY weight TESTOSTERONE ANIMAL experimentation ALBINISM GENE expression RATS COMPARATIVE studies DESCRIPTIVE statistics PLANT extracts ANDROGEN receptors PROGESTERONE receptors EVALUATION |
| Zdroj: | Medico-Legal Update; Jan-Mar2020, Vol. 20 Issue 1, p1016-1032, 7p |
| Abstrakt: | Hibiscus rosa sinensis L. is one of medicinal plant and belongs to the family Malvaceae, Hibiscus species are used in the treatment of many disease, flowers are used to stimulate hair growth, wounds healing activity, anti-parasitic effect, Antidiabetic anti-hyperlipidemic activity. and have many pharmacological properties including anti-fertility, antipyretic, antispasmodic, antifungal, anti-inflammatory and many more. This study was conducted in the department of Biology /College of Science/University of Babylon/Iraq, to evaluate the Effect of Phenolic Extract of Hibiscus rosa - sinensis L. flowers on some biomarkers and gene expression in Albino male Rats .The overall number of animals used were 32 male rats aged 2-3 months. The results showed a significant decrease (p<0.05) in the level of Testosterone and Progesterone in treated rats as compared with control groups for 30 and 60 days. Also the result revealed a significant decrease ( p< 0.05) in the expression of the androgen receptors and progesterone receptor in the testicular cells treatment group with phenolic compounds of H. rosa- sinensis flowers at a dose of 300mg / kg /day of body weight for 60 days compared to control groups. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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