PROSPECTIVE COMPARATIVE STUDY BETWEEN PAP SMEAR, VISUAL INSPECTION WITH ACETIC ACID, VISUAL INSPECTION WITH LUGOL'S IODINE, COLPOSCOPY AND HISTOPATHOLOGY FOR DIAGNOSIS OF CERVICAL INTRAEPITHELIAL NEOPLASIA AND EARLY CARCINOMA CERVIX.

Autor: Gaikwad, Vidya, Gaikwad, Suhas, Yalla, Suneha, Salvi, Pankaj
Předmět:
Zdroj: Journal of Pharmaceutical Negative Results; 2023 Special Issue, Vol. 14, p1817-1826, 10p
Abstrakt: Carcinoma cervix is an important reproductive health problem in women and a leading cause of morbidity and mortality of women from cancer in the developing world. Invasive cervical cancers are preceded by a long phase of precancerous lesions which can be detected by screening and treated effectively by simple curative methods, thus preventing invasive cancer. The present study is aimed to compare the diagnostic accuracy of Pap smear, Visual Inspection with Acetic Acid (VIA)and Lugol's Iodine (VILI),colposcopy and histopathology for screening of premalignant and malignant lesions of the cervix. The study was a hospital based comparative observational study done on 130 married women in the age group of 18-60 years attending the Gynaecology ward. Papanicolaou's smear was taken of patients included in the study and the cervix was visually inspected using 5% glacial acetic acid and Lugol's iodine. The cervix of these patients was examined with colposcope. Biopsy was taken of patients showing acetowhite lesions on VIA, mustard yellow stained areas on VILI and cases with Swede score ≥ 5 on colposcopy. Sensitivity, specificity and accuracy were calculated to analyze the diagnostic value of colposcopy, visual inspection methods and pap smear. The results were compared with that of histopathology of cervix, which is the gold standard. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index