| Autor: |
West, C. D., Winter, Sara, Forristal, Judith, Davis, N. C. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Jan1968, Vol. 3 Issue 1, p57-62, 6p |
| Abstrakt: |
This article presents information on effect of aging of serum of consumption of antibody by beta globulin determinants. The most likely explanation for the increased consumption with ageing is steric changes occurring as the betaIC- molecule fragments into betaIA and alpha2D, resulting in exposure of additional antibody combining sites. In specimens from patients with hypocomplementemic nephritis, the increase in consumption with ageing was less than in normal subjects. The data add to the evidence presented in earlier studies of the presence in vivo, in certain nephritics, of breakdown products of betaIC globulin. The most abundant breakdown product would be alpha2D. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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