| Abstrakt: |
배경: Despite the evidence of treatment for COVID-19 patients changed rapidly, little is known about the patterns of potential pharmacological treatment during the early COVID-19 pandemic in Korea. 방법: Lopinavir/ritonavir and hydroxychloroquine prescriptions for COVID-19 patients were screened between January to December 2020. Prescription after July 2020 were regarded as ineffective according to the revision of the National Institute of Health (NIH) COVID-19 treatment guideline. Individual factors and hospital factors were compared between patients who got prescription of ineffective antiviral candidates and the patients who did not get those. 결과: Ineffective lopinavir/ritonavir and hydroxychloroquine were prescribed in 2,330, and 196 episodes during the study period. Patient factors associated with ineffective antiviral candidate prescription were oxygen supplementation (adjusted odds ratio [aOR] 3.068, 95% confidence interval [95CI] 2.764-3.404), and old age (aOR for 50-64 1.91, 95CI 1.692-2.158, aOR for ≥ 65 1.718, 95CI 1.497-1.971). Patients with medical aid showed negative association (aOR 0.532, 95CI 0.439-0.644). Statistically significant hospital factors were primary and long-term care hospital (aOR 10.875, 95CI 8.388-14.099), 300-700 bed-sized hospital (aOR 2.169, 95CI 1.763-2.669), and located in regions where those antiviral candidates were highly prescribed before the study period (aOR 5.455, 95CI 4.284-6.946). 결론: Ineffective antiviral candidates were prescribed to a substantial number of patients against the guidelines during the first year of COVID-19 pandemic in Korea. Highly associated factors were hospital factors rather than patient factors. [ABSTRACT FROM AUTHOR] |
