| Autor: |
Rigalleau, V., Lasseur, C., Chauveau, P., Barthes, N., Raffaitin, C., Combe, C., Perlemoine, C., Baillet-Blanco, L., Gin, H. |
| Předmět: |
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| Zdroj: |
Annals of Nutrition & Metabolism; Nov/Dec2004, Vol. 48 Issue 6, p409-413, 5p, 1 Chart, 2 Graphs |
| Abstrakt: |
Background/Aims: Lean body mass (LBM) is reduced in uremia, but this has not been reported in diabetic nephropathy. Subjects and Methods: We compared predicted % LBM to DEXA measurements in 10 non-diabetic uremic, 10 non-uremic diabetic and 10 uremic diabetic subjects matched for age, gender and BMI. We also measured % LBM by anthropometry, bio-impedance analysis (BIA) and compared them with DEXA in 49 diabetic subjects with a wide range of renal failure. The results were compared and a Bland & Altman procedure was performed. Associations between glomerular filtration rate (GFR) and % LBM were tested. Results: In matched groups, predicted % LBM values were overestimated in non-diabetic uremic subjects, and underestimated in non-uremic diabetic subjects. In uremic diabetic subjects, the error was intermediary. As compared to DEXA (% LBM: 69.0 ± 7.1%), measurement of % LBM by anthropometry (71.4 ± 8.0%, p < 0.05) and BIA (67.2 ± 7.6%, p < 0.05) were biased in the 49 diabetic subjects. The mean of anthropometric and BIA (Ant+BIA) were similar to DEXA results (69.3 ± 6.8%, p = 0.64), with best correlation coefficients and Bland & Altman plots. GFR was correlated to % LBM assessed by DEXA, BIA and Ant+BIA. Conclusion: In diabetic subjects with chronic kidney disease, LBM should be measured, rather than predicted. A good evaluation is possible, even without DEXA. Copyright © 2004 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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