| Autor: |
Llibre, Josep M., Scholten, Stefan, Osiyemi, Olayemi, Grove, Richard, Oyee, James, Wang, Ruolan, Wynne, Brian, Donovan, Cynthia, Jones, Bryn, Okoli, Chinyere, Kisare, Michelle, Ait-Khaled, Mounir, Gyo-Seung Gu |
| Předmět: |
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| Zdroj: |
Infection & Chemotherapy; 2022 Supplement, Vol. 54, p272-272, 1p |
| Abstrakt: |
Background: Persistent inflammation has been linked to increased risk of non–AIDS-related comorbidities in people with HIV-1. International guidelines recommend the 2-drug regimen (2DR) DTG/3TC as a switch option, supported by randomized clinical trials demonstrating its durable efficacy and high barrier to resistance. We present inflammatory biomarker results in virologically suppressed adults switching to DTG/3TC. Methods: This analysis included 48-week pooled data from the phase 3 TANGO and SALSA trials of adults with HIV-1 RNA <50 c/mL randomized to switch to once-daily DTG/3TC fixed-dose combination or continue current antiretroviral regimen (CAR). Using a multivariate ANCOVA model adjusting for relevant baseline variables, log-transformed Week 48 serum inflammatory biomarker levels and CD4+/CD8+ ratio were compared between groups and associations with baseline variables evaluated as fixed effects. Results: Week 48 soluble CD14 (sCD14) and C-reactive protein (CRP) appeared lower in the DTG/3TC vs CAR groups, and Week 48 sCD163, IL-6, and CD4+/CD8+ ratio were similar between groups (Table). Across biomarkers, higher baseline values were strongly associated with higher Week 48 levels. Female participants had higher Week 48 levels of all inflammatory biomarkers compared with male participants. Asian participants appeared to have lower Week 48 levels compared with other races across all inflammatory biomarkers, although sample sizes were small. Increasing age appeared to be associated with higher sCD14, sCD163, and IL-6 but not with CRP and CD4+/CD8+ ratio. Higher Week 48 IL-6 and CRP were observed in participants with baseline obesity. Conclusion: At Week 48 in this pooled analysis of 2 randomized trials, inflammatory biomarker levels were similar between the 2DR DTG/3TC and a broad range of 3/4DRs. Multiple baseline variables besides ART were associated with each inflammatory biomarker. These data highlight the multifactorial aspect of the inflammatory response. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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