| Autor: |
Šimkovič, Martin, Turcsányi, Peter, Špaček, Martin, Mihályová, Jana, Ryznerová, Pavlína, Maco, Mária, Vodárek, Pavel, Écsiová, Dominika, Poul, Hynek, Móciková, Heidi, Zuchnická, Jana, Panovská, Anna, Lekaa, Mohammad, Oršulová, Martina, Prchlíková, Adéla, Stejskal, Lukáš, Mašlejová, Stanislava, Brychtová, Yvona, Bezděková, Lucie, Papajík, Tomáš |
| Předmět: |
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| Zdroj: |
Annals of Hematology; Apr2023, Vol. 102 Issue 4, p811-817, 7p |
| Abstrakt: |
Patients with chronic lymphocytic leukemia (CLL) have a high risk of poor outcomes related to coronavirus disease 2019 (COVID-19). This multicenter cohort study evaluated the impact of COVID-19 infection on the population of CLL patients in the Czech Republic. Between March 2020 and May 2021, 341 patients (237 males) with CLL and COVID-19 disease were identified. The median age was 69 years (range 38–91). Out of the 214 (63%) patients with the history of therapy for CLL, 97 (45%) were receiving CLL-directed treatment at diagnosis of COVID-19: 29% Bruton tyrosine kinase inhibitor (BTKi), 16% chemoimmunotherapy (CIT), 11% Bcl-2 inhibitor, and 4% phosphoinositide 3-kinase inhibitor. Regarding the severity of COVID-19, 60% pts required admission to the hospital, 21% pts were admitted to the intensive care unit (ICU), and 12% received invasive mechanical ventilation. The overall case fatality rate was 28%. Major comorbidities, age over 72, male gender, CLL treatment in history, CLL-directed treatment at COVID-19 diagnosis were associated with increased risk of death. Of note, concurrent therapy with BTKi compared to CIT was not associated with better outcome of COVID-19. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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