Seroprevalence, trends, and risk factors of hepatitis B and C among family replacement blood donors; a 7-year retrospective study at Sunyani Municipal Hospital, Ghana.

Autor: Osei-Boakye, Felix, Nkansah, Charles, Appiah, Samuel Kwasi, Derigubah, Charles Angnataa, Mensah, Kofi, Apandago, Abraham Azumah, Boateng, Vida Animah, Norsi, Obed Gadufia, Kogh-Nuu, Dominic
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Zdroj: Journal of Immunoassay & Immunochemistry; 2023, Vol. 44 Issue 2, p162-175, 14p
Abstrakt: Hepatitis B and C cause chronic infections which develop into liver-related sequelae, like cirrhosis and liver carcinoma. This study determined the seroprevalence, trends, and risk factors of HBV and HCV among family replacement donors. A retrospective review of primary data on blood donors screened between January 2015 and December 2021 was conducted at Sunyani Municipal Hospital. The data were assessed for seroprevalence, trends, and odds ratios using SPSS. Of 6847 donors, the majority were males (88.1% [6033]), ≤24 years (27.4% [1874]), O blood type (69.8% [4776]), and Rh-positive (89.9% [6154]). The seroprevalences of HBV and HCV were 3.2% and 1.9%, respectively, with more males infected with HBV and HCV (3.4% vs 2.0%). Males were 2.842 times (p =.001) and 2.399 times (p =.025) more susceptible than females to HBV and HCV, respectively. In the rainy season, donors were 1.489 times (p =.041) more susceptible to HCV. HBV and HCV seroprevalence declined over the period (slope: −0.5464, p ≤.001 vs slope: −0.6179, p ≤.001). Male gender and rainy season were significant determinants of both infections. The seroprevalence of HBV was higher than HCV despite the significant decline in both infections. We, recommend health authorities intensify health education among males and during the rainy season. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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