| Autor: |
Wenli Lei, Yuyang Song, Ai Long, Yanyan Que, Shuzhong He, Hang Zhong, Yang Chen |
| Předmět: |
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| Zdroj: |
Frontiers in Plant Science; 12/21/2022, Vol. 13, p1-10, 10p |
| Abstrakt: |
The medicinal plants were wildly library of natural products in drug discovery. The most active molecules with seven-membered rings skeleton represent a challenge for construction. A stereoselectivity (4 + 3) cycloadditions between allenyl ethers and substituted furans induced by chiral auxiliaries has been investigated. And the results showed significant stereoselectivities and regioselectivities. The optical cycloadducts with an oxygen-substituted seven-membered ring framework were generated by removing chiral auxiliaries under acidic conditions. The antiproliferative activity of the novel compounds displayed moderate antiproliferative effects toward T47D cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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