| Autor: |
Moravia, Anaïs, Simoëns, Serge, El Hajem, Mahmoud, Bou-Saïd, Benyebka, Menut, Marine, Kulisa, Pascale, Lermusiaux, Patrick, Della-Schiava, Nellie |
| Zdroj: |
Cardiovascular Engineering & Technology; Feb2023, Vol. 14 Issue 1, p141-151, 11p |
| Abstrakt: |
Purpose: Pulse wave velocity (PWV) is an indicator of arterial stiffness used in the prediction of cardiovascular disease such as atherosclerosis. Non-invasive methods performed with ultrasound probes allow one to compute PWV and aortic stiffness through the measurement of the aortic diameter (D) and blood flow velocity (U) with the lnD–U method. This technique based on in vivo acquisitions lacks validation since the aortic elasticity modulus cannot be verified with mechanical strength tests. Method: In the present study, an alternative validation is carried out on an aorta phantom hosted in an aortic flow simulator which mimics pulsatile inflow conditions. This in vitro setup included a Particle Image Velocimetry device to visualize flow in a 2D longitudinal section of the phantom, compute velocity fields (U), and track wall displacements in the aorta phantom to measure the apparent diameter (AD) variations throughout cycles. Results: The lnD–U method was then applied to evaluate PWV (5.79 ± 0.33 m/s) and calculate the Young's modulus of the aorta phantom (0.56 ± 0.12 MPa). This last value was compared to the elasticity modulus (0.53 ± 0.07 MPa) evaluated with tensile strength tests on samples cut from the silicone phantom. Conclusion: The PIV technique PWV measurement showed good agreement with the direct tensile test method with a 5.6% difference in Young's modulus. Considering the uncertainties from the two methods, the measured elasticities are consistent and close to a 50–60 years old male aortic behavior. The choice of silicone for the phantom material is a relevant and promising option to mimic the human aorta on in vitro systems. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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