| Autor: |
Goncharuk, Oleksii, Savosko, Serhii, Tykhomyrov, Artem, Guzyk, Mykhailo, Medvediev, Volodymyr, Tsymbaliuk, Vitaliy, Chaikovsky, Yuri |
| Předmět: |
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| Zdroj: |
Journal of Neurological Surgery. Part A. Central European Neurosurgery; Mar2023, Vol. 84 Issue 2, p116-122, 7p |
| Abstrakt: |
Fibrosis of the injured muscles is a problem of recovery from trauma and denervation. The aim of the work was to investigate the interconnection of matrix metalloproteinase-9 (ММР-9) activity in denervated muscles with fibrosis and to estimate its role in nerve restoration by the epineurial suture, fibrin-based glue, and polyethylene glycol hydrogel. The activity of matrix metalloproteinases was estimated by gelatin zymography. Collagen density in muscles was determined histochemically. An increased level of the active MMP-9 is associated with the fibrous changes in the denervated skeletal muscles and after an epineurial suture. The use of fibrin glue and polyethylene glycol hydrogel resulted in a lower level of collagen and ММР-9 activity, which may be a therapeutic target in the treatment of neuromuscular lesions, and has value in fibrosis analysis following microsurgical intervention for peripheral nerve reconstruction. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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