Lactate Dehydrogenase Isoenzyme Pattern: Marker for Differentiation of Lymphocytes.

Autor: Plum, J., Monteyne, R., Dhont, E., de Smedt, M.
Předmět:
Zdroj: Scandinavian Journal of Immunology; Jun1978, Vol. 7 Issue 6, p515-518, 4p
Abstrakt: The lactate dehydrogenase isoenzyme pattern has been determined in different murine thymocyte cell populations. Enrichment of thymocytes with more mature cells through total body irradiation results in a smaller percentage of LDH-1, LDH-2, LDH-3 and a greater percentage of LDH-4 and LDH-5. Fractionation of normal thymocytes by velocity sedimentation at unit gravity yields a fraction of cells with a high sedimentation rate. LDH-1 and LDH-2 formed a smaller percentage of the total enzyme activity in these cells. These findings indicate that the LDH isoenzyme distribution is a marker for differentiation of thymocytes. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index