Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk Factor.
Autor: | Lazarovits, Gilad, Ofek Shlomai, Noa, Kheir, Raed, Bdolah Abram, Tali, Eventov Friedman, Smadar, Volovelsky, Oded |
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Předmět: |
PATENT ductus arteriosus
CATHETER-related infections PREMATURE infants NEONATAL intensive care CONFIDENCE intervals MULTIVARIATE analysis VERY low birth weight RETROSPECTIVE studies ACQUISITION of data NEONATAL intensive care units FISHER exact test REGRESSION analysis RISK assessment MEDICAL records CHI-squared test KAPLAN-Meier estimator DESCRIPTIVE statistics ACUTE kidney failure in children INFANT mortality LOGISTIC regression analysis DATA analysis software BLOODBORNE infections ACUTE kidney failure CREATININE DISEASE complications |
Zdroj: | Children; Feb2023, Vol. 10 Issue 2, p242, 12p |
Abstrakt: | Background and objectives: Very low birth weight (VLBW) infants are at high risk of developing acute kidney injury (AKI), presumably secondary to low kidney reserves, stressful postnatal events, and drug exposures. Our study aimed to identify the prevalence, risk factors, and outcomes associated with AKI in VLBW infants. Study design: Records of all VLBW infants admitted to two medical campuses between January 2019 and June 2020 were retrospectively reviewed. AKI was classified using the modified KDIGO definition to include only serum creatinine. Risk factors and composite outcomes were compared between infants with and without AKI. We evaluated the main predictors of AKI and death with forward stepwise regression analysis. Results: 152 VLBW infants were enrolled. 21% of them developed AKI. Based on the multivariable analysis, the most significant predictors of AKI were the use of vasopressors, patent ductus arteriosus, and bloodstream infection. AKI had a strong and independent association with neonatal mortality. Conclusions: AKI is common in VLBW infants and is a significant risk factor for mortality. Efforts to prevent AKI are necessary to prevent its harmful effects. [ABSTRACT FROM AUTHOR] |
Databáze: | Complementary Index |
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