Synthesis of selectively protected α-(1→3)- and α-(1→5)-linked octasaccharide moiety bearing a Janus aglycone, related to the branching site of mycobacterial polysaccharides.

Autor:	Abronina, P. I., Shvyrkina, Yu. S., Zinin, A. I., Chizhov, A. O., Kononov, L. O.
Předmět:	MOIETIES (Chemistry) POLYSACCHARIDES ARABINOGALACTAN AD hoc organizations AGLYCONES GLYCOSIDES
Zdroj:	Russian Chemical Bulletin; Dec2022, Vol. 71 Issue 12, p2740-2750, 11p
Abstrakt:	A novel selectively protected α-(1→3)- and α-(1→5)-linked branched octasaccharide based on arabinofuranose was synthesized via a convergent route as a glycoside with 4-(2-chloroethoxy)phenyl aglycone, belonging to the class of Janus aglycones. The obtained octasaccharide is related to the branching site of lipoarabinomannan and arabinogalactan of mycobacteria. The Janus aglycone moiety can play the role of not only a temporary protective group at the anomeric position of sugar, but also a pre-spacer for the synthesis of neoglycoconjugates useful in the design of new tools for diagnostics of tuberculosis. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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