| Autor: |
Walker, L. A., Johnson, G. D., MacLennan, L. C. M. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Jan1988, Vol. 71 Issue 1, p193-197, 5p |
| Abstrakt: |
In the present study evidence is provided that neoplastic B cells from the blood from four of 24 patients with myelomatosis were activated selectively with polyclonal B cell mitogens. In three of these patients the activated cells produced light chains without heavy chains; of these, two patients had IgGK paraproteins and one had free &lamda; light chain disease. The ratio of κ-expressing to &lamda;-expressing B cells in the initial blood B cell preparations was within the range for healthy controls for all four patients where neoplastic B cells were selectively activated. It is concluded that in some patients with myelomatosis the neoplastic clone is a mosaic of: (1) cells capable of synthesizing both light and heavy chains with (2) cells producing light chains only. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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